Plastic degradation in the environment results in the formation of plastic microparticles and, upon further degradation, plastic nanoparticles. Only limited data is available regarding the impact of these plastic micro- and nanoparticles on human health; despite increasing evidence of their transfer to humans via the food chain. This project investigates the production and characterization of plastic micro- and nanoparticles made from materials commonly used in the packaging industry. These particles are subsequently used as test materials for further in-vitro studies to determine the potential effects of plastic micro- and nanoparticles on human health.