INTEGRATE

INTEGRATE is a multidisciplinary research program funded by the European Innovation Council and the Swiss Secretariat for Education, Research, and Innovation worth €3 million (awarded in 2021). The main goal is to develop energy-autonomous prosthetics and robotic devices.

The scientific coordinator of the INTEGRATE project is Dr. Alessandro Ianiro of the AMI BioPhysics group. Other AMI participants include his colleague Dr. José Berrocal (Polymer Chemistry and Materials) who developed the project with Ianiro, as well as the AMI BioPhysics chair Prof. Michael Mayer, and the Polymer Chemistry and Materials chair Prof. Christoph Weder. The goal is to develop soft actuating devices fueled by metabolic (biochemical) energy, eliminating the need for external power sources for these devices. Implantable materials based on this technology would be similar to healthy muscles, replacing damaged ones, or they would be built into complex prosthetic devices, and powered by small and non-invasive power units integrated within the body.

The ability to transform energy into controlled motion is one of the most intriguing features of living organisms and has inspired the development of technologies capable of performing mechanical operations. This process led to the use of hard and soft machines as implantable medical devices, for instance peacemakers or prosthetics. However, limitations hinder the fulfilment of the enormous potential of implantable actuating systems. These include the mismatch between mechanical properties and biological tissues, the need for bulky devices to activate them pneumatically, or external power sources.

INTEGRATE targets three science-towards-technology breakthroughs to overcome these limitations. First, the development of next-generation soft actuating materials, mimicking the functioning of animal muscles. These bionic muscles (BM) will be soft, biocompatible, multifunctional, power-efficient and will possess actuating properties comparable to human muscles. Secondly, large-scale 3D printing of these materials, allowing for tailor-made BMs for patients. Finally, the creation of an artificial Energy-Harvesting Organ (EHO) capable of harvesting metabolic (biochemical) energy and converting it into electricity. Biosensors would connect the artificial muscles with physiological signals.

The European Innovation Council’s Pathfinder program supports the exploration of bold ideas for radically new technologies. It welcomes the high-risk / high gain and interdisciplinary cutting-edge science collaborations that underpin technological breakthroughs. For the EIC call, only six per cent of applications (56 out of 868 proposals), including INTEGRATE, were successful. The project was also the only one with a Swiss leading house.

Besides AMI, the INTEGRATE project brings together partners from a number of European research institutions:

Laboratory of Physical Chemistry, Eindhoven University of Technology, Eindhoven, The Netherlands

Dipartimento di Ingegneria dell'Impresa "Mario Lucertini", University of Rome Tor Vergata, Rome, Italy

Laboratoire de Physique des Solides, CNRS, Paris, France

VELTHA International Research Association, Brussels, Belgium (administrative coordination)

INTEGRATE project website