Inflammatory respiratory diseases demand innovative therapeutic approaches. Novel drug delivery systems and herbal medicinal products present promising options for both inhalation and systemic treatments. This project focuses on the use of an in vitro lung co-culture model, comprising airway epithelial cells and immune cells, to assess the cellular impact of these molecules. By closely mimicking the in vivo lung environment, the model facilitates a detailed evaluation of cellular interactions and inflammatory responses.

Related publications: 

Drasler, B., Karakocak, B. B., Tankus, E. B., Barosova, H., Abe, J., Sousa de Almeida, M., Petri-Fink, A., & Rothen-Rutishauser, B. (2020). An Inflamed Human Alveolar Model for Testing the Efficiency of Anti-inflammatory Drugs in vitro. Frontiers in bioengineering and biotechnology, 8, 987. https://doi.org/10.3389/fbioe.2020.00987

Barosova, H., Drasler, B., Petri-Fink, A., & Rothen-Rutishauser, B. (2020). Multicellular Human Alveolar Model Composed of Epithelial Cells and Primary Immune Cells for Hazard Assessment. Journal of visualized experiments : JoVE, (159), 10.3791/61090. https://doi.org/10.3791/61090

Magalhães, J., Pinheiro, M., Drasler, B., Septiadi, D., Petri-Fink, A., Santos, S. G., Rothen-Rutishauser, B., & Reis, S. (2020). Lipid nanoparticles biocompatibility and cellular uptake in a 3D human lung model. Nanomedicine (London, England), 15(3), 259–271. https://doi.org/10.2217/nnm-2019-0256