Chronic wounds, such as diabetic foot ulcers, pose significant clinical challenges due to impaired wound healing. This project aims to develop a human skin equivalent model under both healthy and diabetic conditions to investigate the therapeutic potential of nanocarriers for wound healing improvement. The findings will contribute to advanced in vitro models and potential clinical translation.

Funding source: 

Funded by FAPESP (São Paulo Research Foundation) – BEPE Program (Research Internship Abroad Program) (number: 2024/08941-3). 

FAPESP link: https://fapesp.br/ 

Related publications: 

Cultivating a three-dimensional reconstructed human epidermis at a large scale.  

Dijkhoff, I. M., Petracca, B., Prieux, R., Valacchi, G., Rothen-Rutishauser, B., Eeman, M. 

Journal of Visualized Experiments (2020) 

Simvastatin and adenosine-co-loaded nanostructured lipid carriers for wound healing: Development, characterization and cell-based investigation 

Daré, R. G., Costa, A. B. C., Martins, T. S., & Lopes, L. B.  

European Journal of Pharmaceutics and Biopharmaceutics (2024)