With rising concerns about micro- and nanoplastics as emerging risks to human health, the scientific community is striving to develop reliable methods for toxicity assessment. This study explores the feasibility of Raman microscopy, leveraging its ability for label-free chemical mapping, to identify spectral indicators of cellular stress and evaluate micro- and nanoplastic-induced toxicity at the molecular level.

Funding sources:

German Academic Exchange Service https://www.daad.de/de/  

Related publications: 

Haessler A, Jung N, Windbergs M. Unraveling Molecular Composition in Biological Samples-Systematic Evaluation of Statistical Methods for the Analysis of Hyperspectral Raman Data. Anal Chem. 2023 Dec 5;95(48):17646-17653. doi: 10.1021/acs.analchem.3c03368. 

Haessler A, Candlish M, Hefendehl JK, Jung N, Windbergs M. Mapping cellular stress and lipid dysregulation in Alzheimer-related progressive neurodegeneration using label-free Raman microscopy. Commun Biol. 2024 Nov 15;7(1):1514. doi: 10.1038/s42003-024-07182-6.