Person | Adolphe Merkle Institute | Université de Fribourg

COSTABILE Gabriella

gabriella.costabile.unifr.ch.jpg

Alumni

Guest, BioNanomaterials

0000-0002-7370-1348

Publications

State-of-the-Art Review on Inhalable Lipid and Polymer Nanocarriers: Design and Development Perspectives
Gabriella Costabile, Gemma Conte, Susy Brusco, Pouria Savadi, Agnese Miro, Fabiana Quaglia, Ivana d’Angelo, Francesca Ungaro
Pharmaceutics 16 , 347 (2024)

Sustained-Release Powders Based on Polymer Particles for Pulmonary Delivery of Beclomethasone Dipropionate in the Treatment of Lung Inflammation
Emanuela Fabiola Craparo, Salvatore Emanuele Drago, Gabriella Costabile, Maria Ferraro, Elisabetta Pace, Roberto Scaffaro, Francesca Ungaro, Gennara Cavallaro
Pharmaceutics 15 , 1248 (2023)

Hybrid Lipid/Polymer Nanoparticles to Tackle the Cystic Fibrosis Mucus Barrier in siRNA Delivery to the Lungs: Does PEGylation Make the Difference?
Gemma Conte, Gabriella Costabile, Domizia Baldassi, Valeria Rondelli, Rosaria Bassi, Diego Colombo, Giulia Linardos, Ersilia V. Fiscarelli, Raffaella Sorrentino, Agnese Miro, Fabiana Quaglia, Paola Brocca, Ivana d’Angelo, Olivia M. Merkel, Francesca Ungaro
ACS Applied Materials & Interfaces 14 , 7565-7578 (2022)

Intra-tracheal administration increases gallium availability in lung: implications for antibacterial chemotherapy
Emma Mitidieri, Daniela Visaggio, Emanuela Frangipani, Carlotta Turnaturi, Domenico Vanacore, Romina Provenzano, Gabriella Costabile, Raffaella Sorrentino, Francesca Ungaro, Paolo Visca, Roberta d’Emmanuele di Villa Bianca
Pharmacological Research 170 , 105698 (2021)

Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles

Bioengineering & translational medicine (2021)

Characterization of spray dried powders with nucleic acid-containing PEI nanoparticles
Tobias W.M. Keil, Daniel P. Feldmann, Gabriella Costabile, Qian Zhong, Sandro da Rocha, Olivia M. Merkel
European Journal of Pharmaceutics and Biopharmaceutics 143 , 61-69 (2019)

PEGylated mucus-penetrating nanocrystals for lung delivery of a new FtsZ inhibitor against Burkholderia cenocepacia infection
Gabriella Costabile, Romina Provenzano, Alberto Azzalin, Viola Camilla Scoffone, Laurent R. Chiarelli, Valeria Rondelli, Isabelle Grillo, Thomas Zinn, Alexander Lepioshkin, Svetlana Savina, Agnese Miro, Fabiana Quaglia, Vadim Makarov, Tom Coenye, Paola Brocca, Giovanna Riccardi, Silvia Buroni, Francesca Ungaro
Nanomedicine: Nanotechnology, Biology and Medicine 23 , 102113 (2019)

The Impact of Nylon-3 Copolymer Composition on the Efficiency of siRNA Delivery to Glioblastoma Cells
Natascha Hartl, Friederike Adams, Gabriella Costabile, Lorenz Isert, Markus Döblinger, Ximian Xiao, Runhui Liu, Olivia M. Merkel
Nanomaterials 9 , 986 (2019)

Lipids and polymers in pharmaceutical technology: lifelong companions.
Juergen Siepmann, Amina Faham, Sophie-Dorothée Clas, Ben J. Boyd, Vincent Jannin, Andreas Bernkop-Schnürch, Hang Zhao, Sébastien Lecommandoux, James C. Evans, Christine Allen, Olivia M. Merkel, Gabriella Costabile, Morgan R. Alexander, Ricky D. Wildman, Clive J. Roberts, Jean-Christophe Leroux
International Journal of Pharmaceutics 558 , 128-142 (2019)

Evaluation of β-Sitosterol Loaded PLGA and PEG-PLA Nanoparticles for Effective Treatment of Breast Cancer: Preparation, Physicochemical Characterization, and Antitumor Activity
Moses Andima, Gabriella Costabile, Lorenz Isert, Albert J. Ndakala, Solomon Derese, Olivia M. Merkel
Pharmaceutics 10 , 232 (2018)

Physicochemical and In Vitro Evaluation of Drug Delivery of an Antibacterial Synthetic Benzophenone in Biodegradable PLGA Nanoparticles.
Gabriella Costabile, Kathrin I. Gasteyer, Venkatereddy Nadithe, Katherine Van Denburgh, Qian Lin, Shiv Sharma, Joshua J. Reineke, Steven M. Firestine, Olivia M. Merkel
AAPS PharmSciTech 19 , 3561-3570 (2018)

Mannose and Mannose‐6‐Phosphate Receptor–Targeted Drug Delivery Systems and Their Application in Cancer Therapy
Elena Dalle Vedove, Gabriella Costabile, Olivia M. Merkel
Advanced Healthcare Materials 7 (2018)

Hybrid Lipid/Polymer Nanoparticles for Pulmonary Delivery of siRNA: Development and Fate Upon In Vitro Deposition on the Human Epithelial Airway Barrier.
Ivana d'Angelo, Gabriella Costabile, Estelle Durantie, Paola Brocca, Valeria Rondelli, Annapina Russo, Giulia Russo, Agnese Miro, Fabiana Quaglia, Alke Petri-Fink, Barbara Rothen-Rutishauser, Francesca Ungaro
Journal of Aerosol Medicine and Pulmonary Drug Delivery 31 , 170-181 (2017)

Development of inhalable hyaluronan/mannitol composite dry powders for flucytosine repositioning in local therapy of lung infections.
G. Costabile, I. d'Angelo, R. d'Emmanuele di Villa Bianca, E. Mitidieri, B. Pompili, P. Del Porto, L. Leoni, P. Visca, A. Miro, F. Quaglia, F. Imperi, R. Sorrentino, F. Ungaro
Journal of Controlled Release 238 , 80-91 (2016)

Large Porous Particles for Sustained Release of a Decoy Oligonucelotide and Poly(ethylenimine): Potential for Combined Therapy of Chronic Pseudomonas aeruginosa Lung Infections.
Ivana d’Angelo, Brunella Perfetto, Gabriella Costabile, Veronica Ambrosini, Pina Caputo, Agnese Miro, Roberta d’Emmanuele di Villa Bianca, Raffaella Sorrentino, Giovanna Donnarumma, Fabiana Quaglia, Francesca Ungaro
Biomacromolecules 17 , 1561-1571 (2016)

Skin transport of PEGylated poly(ε-caprolactone) nanoparticles assisted by (2-hydroxypropyl)-β-cyclodextrin.
Claudia Conte, Gabriella Costabile, Ivana d’Angelo, Marianna Pannico, Pellegrino Musto, Gianluca Grassia, Armando Ialenti, Pasquale Tirino, Agnese Miro, Francesca Ungaro, Fabiana Quaglia
Journal of Colloid and Interface Science 454 , 112-120 (2015)

Toward Repositioning Niclosamide for Antivirulence Therapy of Pseudomonas aeruginosa Lung Infections: Development of Inhalable Formulations through Nanosuspension Technology.
Gabriella Costabile, Ivana d’Angelo, Giordano Rampioni, Roslen Bondì, Barbara Pompili, Fiorentina Ascenzioni, Emma Mitidieri, Roberta d’Emmanuele di Villa Bianca, Raffaella Sorrentino, Agnese Miro, Fabiana Quaglia, Francesco Imperi, Livia Leoni, Francesca Ungaro
Molecular Pharmaceutics 12 , 2604-2617 (2015)