Human air-blood barrier analogue using innovative bioprinting technology

The lack of a trustworthy, reproducible and commercially available 3D in vitro lung model represents a major bottleneck for the development of efficacious and safe medicines and risk assessment for inhaled xenobiotics, e.g. environmental particulates or combustion-derived particles.

In an ongoing project a bioprinter has been adapted to engineer human lung tissue applying a layer-by-layer printing approach. The proof-of-concept of printed lung tissue will allow us to provide a realistic, automatized and easy to handle in vitro model for hazard assessment in the field of regulatory toxicology as well as for the development of new inhalative medicine.


Principal investigator

Involved people

External partners

regenHU Ltd.

Biosystems Architects, Villaz-St-Pierre

Publications

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Adolphe Merkle Institute - Chemin des Verdiers 4 - CH-1700 Fribourg - Phone +41 26 300 9254